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how does cbd oil interact with other medications

Does CBD Interact with Other Medications?

In a nation where prescription drug use is rampant, the issue of med interactions is sure to rear its head. Big Pharma introduces new prescription drugs to the market annually, and there are thousands available. The Government’s recent National Health Survey found that approximately 20% of American adults take 3+ drugs. An FDA expert believes a massive percentage use at least two.

Research by JAMA Internal Medicine found that 36% of seniors use at least fivedrugs or supplements! 15% of seniors are at risk of significant drug interactions. Sometimes, a physician prescribes a cocktail of medication to a patient. The goal is to create beneficial interactions that enhance the effect of drugs. Sadly, there are occasions where the doctor gets it wrong, and patients become ill or even die.

Logically, the more drugs you take, the higher the risk of a drug interaction. Incredibly, there is a 15% chance if you take two medications. The risk increases to 40% for five drugs, and 80% for seven drugs! It is of greatest concern for seniors due to their extensive usage of prescription medications.

A growing number of people use CBD to try and combat the symptoms of medical conditions. Popular uses for the compound include as a means of reducing epileptic seizures, and to reduce anxiety. While the cannabinoid has a good safety profile, there is the question of CBD interactions. It turns out that there are CBD oil interactions with certain drugs. In this article, we explore the issue in greater depth.

How CBD Interacts with Drugs and Medication

The length of the drug interactions list may surprise you. CBD drug interactions are more prevalent than you think. The most common one relates to Cytochrome P450 (CYP 450) enzymes. Up to 60% of all medications on the market get broken down by this class of enzyme. Let’s check out a few more med interactions featuring cannabidiol.

CBD & CYP 450 Enzymes

The reason why CBD causes so many potential drug interactions is down to its effect on the CYP 450 enzyme. You find it in the liver, and it’s responsible for metabolizing possible toxic compounds. This class of enzymes metabolizes up to 60% of pharmaceutical drugs. When determining the right doses of drugs, physicians make their calculations based on the CYP 450 enzymes. They decide how long it takes for a certain drug to pass through the system.

At sufficient doses, CBD temporarily deactivates CYP 450 enzymes. This process has a significant impact on how we metabolize drugs. According to preclinical research, the CYP 450 class of enzymes metabolize CBD. However, cannabidiol becomes a competitive inhibitor and stops the enzymes from metabolizing other compounds.

The extent of CBD’s effect on CYP 450 depends on how tightly it binds to the active site of the enzyme before and after oxidation. This action varies according to the CBD dose, the form of administration, and the unique attributes of the user. CBD won’t affect CYP 450 when taken in small doses.

A report from 2013 looked at GW Pharmaceuticals’ Sativex, a sublingual spray containing CBD and THC. It found no interaction when patients used 40mg of CBD. However, a later clinical trial discovered that just 25mg of orally administered CBD was enough to block an anti-epileptic drug’s metabolization.

In summation, CBD inhibits the CYP 450 system of enzymes. When the proteins can’t perform their function, too much of a drug enters the liver. It flows to the bloodstream unprocessed. It subsequently increases the risk of having dangerously high levels of drugs in your system. Given the rate of opioid overdose deaths, it is an essential piece of information.

Grapefruit & Drugs

Those who have used medication in the past are probably aware of the ‘grapefruit’ warning that appears on certain drugs. In this instance, you are not supposed to eat grapefruit when using the medication due to a possible interaction. This is because grapefruit contains furanocoumarins. These compounds bind with and neutralize, CYP 450 enzymes. As with CBD, it causes excessive levels of a drug to get into the bloodstream.

CBD is arguably even more of an issue than grapefruit because it binds in several parts of the liver and gut. In contrast, grapefruit primarily impacts enzymes within your small intestine. After CBD inhibits an enzyme, it can take days for its function to return to baseline levels.

A study by Yamaori S., published in Drug Metabolism and Disposition in November 2011, looked at CBD’s effects on CYP2D6. The researchers found that cannabidiol was also a potent inhibitor of CYP3A4. Both enzymes affect drugs such as antidepressants, antihistamines, and statins.

The enzymes inhibited by CBD and grapefruit potentially break down a vast range of OTC drugs as well. In theory, a low dose of medicine could become a high dose if not broken down correctly. A high dose could turn into an overdose. There is a particular risk with drugs that have a narrow therapeutic window.

Beta-Blockers

CBD lowers blood pressure and reduces anxiety, just like beta-blockers. Indeed, both options produce a variety of similar results, and CBD oil potentially carries fewer side effects. However, take both together and you may experience a rapid drop in blood pressure. As a result, you could feel dizzy, weak, and lethargic. In some instances, you could faint or go into shock.

Antidepressants

CBD also inhibits the system that metabolizes a high percentage of SSRIs, antipsychotics, and tricyclic antidepressants. In theory, using cannabidiol with any of these drugs could interfere in how they are metabolized.

Blood Thinners

If you take certain blood thinners with CBD, they are potentially subject to prolonged activity and an increased effect. Moreover, cannabidiol could increase the levels of medication in your blood. This process enhances the risk of adverse side effects.

Metformin

Individuals use metformin to manage diabetes. Early research indicates that CBD’s anti-inflammatory properties could also aid patients with diabetes. However, the cannabinoid could counter metformin’s effect of lowering blood sugar.

Hydrocodone/Paracetamol Interactions

Research into how hydrocodone interacts with CBD is limited. However, mixing this powerful drug with cannabis could suppress your central nervous system to dangerous levels.

At present, there is no known CBD interaction with paracetamol. Next, let’s check out the drugs you should avoid when using CBD.

What Drugs Should You Not Take With CBD?

Given the likely safety profile of the cannabinoid, there are a surprising number of CBD drug interactions. As you will see later, it has a lot to do with the CYP 450 enzymes. As a consequence, there are possible CBD oil drug interactions with the following:

  • Steroids
  • PPIs
  • NSAIDs
  • Oral hypoglycemic agents
  • Anti-epileptics
  • Benzodiazepines
  • HIV antivirals
  • Prokinetics
  • Antihistamines
  • Calcium channel blockers
  • Immune modulators
  • Sulfonylureas

The above is not a full list of all possible drugs impacted by CBD. Also, not every medication within the above categories causes an interaction. As a result, we recommend consulting with a medical professional before trying CBD oil.

What Medications Does CBD Interfere with?

CBD oil interactions occur with drugs that are also metabolized in the body by CYP 450 enzymes, CYP3A4, and CYP2C19. The United States Department of Health has created a list of medicines that are possibly subject to CBD oil interaction.

Here is a list of drugs that cause a medication interaction when used with CBD:

  • Calcium Channel Blockers: Tiazac, Norvasc, and Cardizem.
  • Tricyclic Antidepressants: Amitriptyline, doxepin, and protriptyline.
  • A Variety of Antipsychotics
  • Sildenafil: Viagra, Levitra, and Cialis.
  • Benzodiazepines: Valium, Xanax, and Klonopin.
  • Antihistamines: Allegra, Benadryl, and Xrytec.
  • HIV/AIDS Medications
  • Opioids: Oxycodone and codeine.

Does CBD Oil Interact with Antidepressants?

Yes! Be wary when using CBD oil and antidepressants together. According to the National Alliance on Mental Illness, up to 20% of American adults live with a mental illness. NBC News reported that 17% of U.S. residents take a form of psychiatric medication. Antidepressants are the most widely prescribed.

Peter Grinspoon of Harvard Medical School, says that in general, you can use CBD supplements with antidepressants safely. However, he cites some concerns. For one thing, the CBD market remains unregulated. You must get your CBD from a reputable supplier.

The other primary concern is the lack of clinical evidence. Grinspoon asserts that CBD has hypothetical drug interactions. However, we don’t know if they are clinically significant. He continued by pointing out how CBD inhibits two central enzyme systems and discussed the grapefruit issue.

Grinspoon looked at CBD and SSRIs. He notes that CBD inhibits the system that metabolizes this form of drug. If you are taking psychiatric medication, the last thing you need is interference in how it is metabolized. Nonetheless, Grinspoon confidently stated that most harmful CBD interactions are theoretical. He said that CBD had a minimal side effect profile. Grinspoon also hasn’t heard of ‘clinical decompensation’ issues due to the addition of CBD.

Interaction Between CBD and Chemotherapy Drugs

You must also show caution when undergoing chemotherapy treatment. A growing number of patients use cannabidiol to manage symptoms such as vomiting and nausea. Common chemotherapy drugs include Paraplatin, Doxorubicin, and Ellence.

An inadequate amount of a drug means it won’t provide relief. However, too much could lead to toxicity. It is a fine line between therapeutic benefits and harmful side effects. Doctors use the CYP 450 to calculate suitable doses. If the enzyme system is inhibited, it makes their job a lot more complicated. This is what happens when you add CBD to the mix. The cannabinoid could cause excessive concentrations of the drug to enter the bloodstream, with toxic results.

Consult a Doctor Regarding CBD Medication Interaction

Medication interaction is a grave matter. Drug-drug interactions occur when two medications react with one another. In some cases, the drug has less of an effect. In other instances, too much of the medicine gets into the system. Certain combinations are dangerous. For example, mixing a sedative with an antihistamine could significantly slow your reactions. Suddenly, driving a vehicle or operating heavy machinery are actions fraught with peril.

Research suggests that there are CBD oil interactions with a wide variety of drugs. It all relates to how cannabidiol inhibits the CYP 450 class of enzymes. These are responsible for the metabolization of over half the drugs on the market.

Ideally, you will get in contact with a physician before using CBD if you are on other drugs. In most cases, you should not use cannabidiol with any medicines that carry a ‘grapefruit’ warning. While there is no evidence of a high risk, it is better to be safe than sorry!

CBD oils that work

Customer Reviews Based on 66 reviews

  • Amy Passarelli
    Bring to notice

    CBD is yes an incredibly safe and therapeutic medication, but I would say that always consult your doctor when you are mixing two things together at the same time. Also in case of any emergency, your doc would then know as to why it happened and would be able to manage it in a more appropriate manner.

  • Mike
    Interactions of Inhalers and oxygen and CBD oil?

    I take many inhalers and oxygen, will CBD oil cause any problems or should
    I just go off all of them and only need to take CBD oil.
    Thanks

  • Tim
    Read carefully

    Researchers have found that CBD inhibits the enzymes CYP3A4 and CYP2D6. These are both major metabolizing enzymes for our body, which means CBD has the potential to interact with many substances.

  • Mary Stevens
    Works well always

    To me CBD has never interacted of interfered with other forms of medication. I have tried it with antibiotics, with weed, with multivitamins, it works well for me without any side effects always.

  • Carol
    Thank you!

    I am trying to get off Ativan as I’m so nervous I cry in despair.
    I cut from 3 to 2 a day and it’s so hard. Cbd helps but it takes allot to counterattack my severe nervousness. Thank you for this article. God knows we try to get off these meds that doctors feed to us so they can keep us in bondage to them as they sip of the highlife. This world is ready for a change to help the innocent be freed from big pharma for good. Lord help us all

  • Duane
    How,about CBC balm interactions?

    I may be interested in using a cbd BALM to help alleviate chronic hip and/or lower back pain. Would the drug interactions then perhaps be reduced, in comparison to taking the oil form internally? Or would it be more effective just to take the oil form (orally) for my hip and back pain?

  • Diane Keets
    Thank you for helping

    Thank you for this. I am sadly on a very large amount of meds, all of which are different and probably some shouldn’t be used together. I would love to try CBD for my depression, but worry it will end badly.

  • Linda
    Drug interaction

    I take 7.5mg (half tablet) of mirtazapine to help me sleep 2 or 3 times a week and it normally works very well. Started using cbd oil for anxiety yesterday. Took about 50mg around 4pm (intended to take 20mg but used dropper incorrectly!). Took mirtazapine around midnight but it didn’t help with sleep as it usually does. Is it likely the cbd oil stopped it from working?

  • Harry Steele
    No problems

    I have always drank and taken CBD – no issues

  • Glenda Maul
    ADD

    Can CBD oil be combined with focalin xr for ADD???

  • Steve R Edwards
    I take diltiazem 120 mg,can i also take cbd oil with that?

    can i take cbd oil and diltiazem the same day

  • Paula Jacobs
    Large dosage, when you mention that large daily dosage could effect the liver, what would you consider that amount to be?

    Your article mentions large daily dosage can effect the livers ability to break down rx meds. What would that amount be in your opinion. I have 98% pure oil and the dosage is two 1/2 droppers full twice a day. I have patients concerned about the effect it will have on their blood thinners. CBD opens up receptors in the body and medications will actually work better.

  • Jacqueline martin
    Ms

    Can I take CBD capsules with my other medications- ie = aspirin, amlodipine, bisoprolol, levothyroxine, isosorbide lansoprasole, I had stents put in last year as arteries closing ,& now on atorvastatin 20mg.but I have very painful hip joints & the meds given were paracetamol & co-codermol which do not really touch the ache & pain, I want to know if I could try CBD with the medication that I take already & would this affect my affect medications I take for angina?

  • Nathaniel Mapson
    Advice for athletes

    Does CBD interact with workout supplements such as creatine and protein powders as I use these heavily?

  • John Hernandez
    who can find ?

    You say to consult your physician before taking any of these oils? My question is who knows of a doctor honest enough to tell you the truth on his drugs vs., cbd oils??

  • John Ainsworth
    Help Im an alcoholic

    This is so informative and thorough, thank you for the research! I am looking to start taking CBD for my muscle pain but i am an alcoholic and although I am trying to get help i am worried CBD will impact me badly.

  • Jerry Kraemer
    Propranolol and cbd oil

    I have an essential body tremor and take memorabilia 40 mg daily The propelling keeps my blood pressure at 120/75 but does nothing for my tremor would cbc help my tremor? Does it interact with propranolol? Thanks for any information.

  • Margaretaboile
    Specific Inquest

    I would favor to meet up along anybody at all absorbed with snatching other involved in civil problems about our specialty, connect with me direct using my forum that you think the similar.

  • Emily
    CBD oil and Guanficine

    Hello,
    Thank you for this detailed and understandable explanation about how CBD oil can interact with other drugs. My daughter has Autism and along with that ADHS and Generalized Anxiety Disorder. She takes Buspar for the anxiety, 30 mg daily and Guanficine for the ADHD, 3 mg daily. Guanficine is one of those drugs that one would not consume grapefruit while taking. I am now driving CBD oil to my daughter and it halls with a myriad of things, even she notices the difference. I am currently given her 12 mg in the morning and 12 mg in the evening. Is this safe? Thank you

  • Alex
    Thanks for the info!

    With so much info and anecdotes about the wonders of CBD, I think more people need to see this in particular! I have never seen another article say about the dangers of mixing CBD and other pharma drugs and so this is so important! Thanks for the info!

  • Elisha
    Tylenol

    Can i take Tylenol with my cdb honey stick of 10mgs?

  • Jen Garrnet
    Eliquis Interaction

    I take 5 mg Eliquis twice a day for AF. I have fibromyalgia with sleep issues and moderate pain and am interested in taking no more than 10 mg per day CBD. Is that safe and does taking it sublingually make a difference with any potential Eliquis interaction? Thank you in advance for any advice.

  • Paul Reade
    Can I take cbd and Omeprazole?

    Can I take cbd and 20 mg Omeprazole?

  • Bryan
    CBD recover after exercise?

    I have been on meds for my high cholesterol for 8 months, and want to try CBD to help me recover after exercise as I have started running to help with the cholesterol – do you think this is okay?

  • Colleen Stadnick

    I’m currently taking Warfarin and really hate it and am thinking about switching to Eliquus. How does CBD oil interact with that? Also how about Sertraline (Zoloft), Atenolol, Digoxin and Primidone? Thanks.

  • Pete Marlow

    I am an avid runner – so recently I have been seeing all about how CBD can be great for athletes, and I wanted to try it out for myself. Smoking was a no go – so I tried the Charlottes Web oil pen – and wow does it help! I just apply the oil to my knees after a long distance run and the pain and swelling seems go reduce in no time, it’s great!

  • Ross Jones

    The Charlotte’s Web oils have provided me with a wealth of benefits – not least and most unexpectedly is how well I can get off to sleep at night now! I didnt buy the oil for that purpose, so it a great surprise!

  • Janel Williams

    I have been using the everyday hemp oil for 4 weeks, at the recommended 1ml amount. So far I am finding the results very effective. I have suffered from eczema for years and this seems to really help clear my skin and reduce itchy flakey symptoms!

  • Michael Ranger

    First of all thank you for such an in-depth post, it is really valuable information that you are sharing Jonathan. I do take some of the medications you mentioned here, and I have yet to visit the GO about my CBD use so I think now after reading this I will be going to discuss my options – thank you!

  • Brian Lowe

    I have been taking CBD for my arthritis for about 12 months. I have very high cholesterol and I am also on cholesterol medication, but I haven’t been taking these as often because I don’t want to give up my CBD. What would you advise? I am fearful of going to the doctor in case they tell me to stop taking CBD as it helps my pain so much.

    • norma
      reduce or eliminate cholestrol meds w/Dr.

      I have always wondered if the cholesterol drugs work. Checking with your doctor, of course, find an alternative that is more natural. Check with a holistic doctor. It is a shame that something that works for your pain should be avoided.

  • Linda Maclellan

    Hi Johnathon, I’m taking 1.5 mgs off clonazepam for anxiety and nerves. Will taking CBD oil give me side effects? I just finished cancer treatment…..chemotheraphy (cisplatin) a very low does. I took it once a week for 5 weeks. I also had radiation therapy. Will the CBD oil effect my metabolism, anxiety and nerves?

  • Louise

    Hi i suffer from anxiety and take 100mg quetiapine at night. I have been to gp today and they have put me propranolol 40 3 times a day? Would i be able to uave cbd oil or will it interact i dont really want to ask my doctor at present as thwy will put me off cbd oil???

    • Jonathan Miller

      Using CBD together with Quetiapine may increase side effects such as dizziness, confusion, drowsiness and difficulty concentrating. Please consult with your doctor prior to consuming any CBD

  • Mai Lou

    Which CBD products would you recommend for epilepsy? I haven’t tried CBD yet as i have only recently been diagnosed and unsure what products to try for the better?

  • Filip

    Hi Jonathan i am tapering of mirtazapine, i am down to 30mg from 60 so half way, can i start cbd oil treatment for uc now or do i have to wait to more months until mirta free?
    i have cibdol 4% cbd oil
    please answer quickly, my ulceratis colatis is getting bad again:(
    regards

    • Jonathan Miller

      Hi Filip, I would love to help but I have never used cibdol. I would reach out to the company

  • Anonymous

    Dear Jonathan
    I’m about to take cbd oil for chronic back pain whilst waiting for surgery. I’m on an anti coagulant, Riveroxabane. A syatin

    • Brenda
      Cbd oil and celebrex

      Hello,
      I take Celebrex 100mg twice a day for osteoarthritis and started taking some cbd oil but am feeling quite “ whoozy” should I stop the Celebrex or cbd?

      • Dr. Joe
        celebrate and cbd oil

        Is it sensible that you added cbd oil to your treatment, then you became woozy, that cbd oil is your cause?

  • Maria

    Hi, I am currently taking cellcept, plaquenil, celexa, bupropion. I am currently taking a full dropper at night of elixinol which has 5mg of cbd and 16.7 of hemp oil. Will any of these meds counter act with the cbd oil?

    • Jonathan Miller

      A general good rule of thumb is to find out if your medication is sensitive high levels of citric acid. If so it may not interact well with CBD. FYI:Cytochrome P-450 is an enzyme produced by the liver, which is responsible for about 90 percent of the drug metabolisms that take happens in the body. Cannabidiol tends to suppress this. Therefore if you are taking a drug that interacts with the Cytochrome P-450 the CBD could have a negative impact. Always consult with your doctor before any CBD consumption.

  • Sue

    Can you take CBD oil with taking 20mg of warfarin

  • sherri long

    hello, is 15 mg cbd oil, charlottes web, enough of a dose to try for anxiety?
    I also take prozac 40mg and simvastatin 40mg and ziac, which is a beta blocker/diuretic for blood pressure.
    thanks for your thoughts,

  • Donna Podobinski

    I would like to know what effects are possible when taking CBD oil with the BP meds losartan/hydrochlorothiazide 100/25, and the opiod hydrocodone/acetaminophen 10-325,4-5 times daily.
    I am just beginning the process of decreasing the losartan while beginning the CBD oil. My
    moderate to severe pain is from an assortment of concurrent spinal diseases and sacral/ lumbar arthritis from repetitive injury.
    I am using CBD at 300 mg and realize that my optimum dosing should be with 1000mg, but all the sites suggest starting low and progressing. My breakthrough pain does not respond to 300mg at 1/2 dropper. Higher CBD levels increase interactions. Any help in deciding is greatly appreciated. Thank you in advance.

  • Kip Henderson

    First off let me thank you for putting out a truthful guide to drug interactions between CBD oil and pharmaceutical medications rather than just spouting the party line. But, like everyone else on here I do have a couple of questions. I was told by my family doctor who prescribed the medical marijuana that it didn’t interact with “any” of the pharmaceuticals I was taking. Yet, when I read your blog I see that the FDA has said that it inhibits the liver metabolizing of pretty much every pharmaceutical drug I take which includes diclofenac (arthrotec), citerizine hydrocloride(reactin), Esomeprazole(nexium), and Rosuvastatin(crestor) . So, given the fact that it screws up the metabolizing of those pharmaceuticals would it be safe or prudent for me to use CBD oils in combination with all these pharmaceuticals or would I be playing Russian roulette especially with the Diclofenac which, along with an extended effectiveness has the potential serious liver and blood issues over time despite the daily dosage of the CBD oil used.

  • Gloria Mulcahy

    Hi Jonathan,
    I live in Ireland where its relatively new that CBD oil is available, just to tell you i have been suffering 5 years with bulging discs and only a month ago had an epidural for the second time and to be honest i am 100 times worse since having it done. My regular every day meds are Aspirin 75mg as a maintenance dose, lustral 100mg, Rosuvastatin 10mg & Nexium 40mg. Now since coming out of hospital for the past month i am on pregablin {Lyrica} 75mg 3 times daily, Targin 10/5mg 2 per day 12 hours apart, Tramadol 50mg up to 3 times per day when needed and paracetamol when needed. I finally today was able to buy CBD + Jacob Hooy 10 ml of 2,75% [If that makes any sense as thats whats on the bottle] so my questions are, how soon can i take it, do i stop taking the meds since coming out of hosp first,? I would appreciate your reply and recommendation. I am in terrible pain down my right leg from sciatic nerve & foot goes numb. I also have fibromyalgia. Thanks Jonathan.
    Kind Regards, Gloria.

  • Peter cross

    Is it safe to tack if with out inform,ming my doc,simms diabetic neiopathic Pain, insulin,met form, auto arthritus

  • Ashton Huffman

    I take 30 mg’s Of diazepam a day for 5 years plus 5mg’s of lisinopril. The diazepam doesn’t help my anxiety and panic at all but it helps my vertigo. Is it safe to take the oil with my current meds?

    • Jonathan Miller

      In my experience they shouldn’t interact but again speak to your doctor.

  • Irene

    I am suffering greatly with I think IBS or Diverticulitis . I take Warfarin for AF, Cardicor. . Losartin.and simvastatin. Would it be wise of me to try the CBD OIL to try to relieve my painful. Stomach . I appreciate your wise advice .

  • Nancy

    My 14 yr old is on Latuda. 60mg once daily at night. I have just purchased my first everyday advanced hemp oil?
    What advice do you have?

  • Shannon Thier

    Will lexapro interact with the CBD oil?

  • Jo Christensen

    Does CBD oil interfere with Prednisolone (note: not Prednisone) or vice-versa? I am considering very low dose CBD oil in lieu of toxic chemotherapy for my cat’s intestinal lymphoma, but would like him to stay on the Prednisolone so as to keep-up his appetite and general well-feeling. Note that he will also need to continue Sucralfate for another week or two in order to heal a stomach ulcer.

  • JOHN FEDORUK

    i take cocersyl plus for blood pressure// started taking 15 drops of straight CBD 3 times a day,
    doing my regular routine and my BP reading went through the roof 170/95 after the 1st day
    normal readings for me were 130/78, should i stop the cbd

  • Raj

    Do you know if CBD oil can conflict with ayurvedic natural medicines. I read on your site that certain enzymes in the liver to break down medicines might be deactivated due to CBD oil. Appreciate your view.

  • Ron Teck

    How does hemp oil react with antihistamines and blood pressure meds, are there any risks.

  • Tammy M

    Oh and from what I understand is it’s made my meds more potent is why it dropped the BP so much. It does drop BP some but it warned that it could make meds more potent

  • Tammy M

    I am on Toprol er, Lisinopril, Verapamil sr, and Hydrochlorothiazide and have been for over 5 years. This is the only combo of drugs that has ever gotten my blood pressure close to normal. It still stays on the high side of normal but at least I have had that. Putting that aside, I started on and for pain about 2 months ago and my BP started dropping. Now I started getting numbers like 84/49 and 90/51 so I immediately started doing things to pull my BP up like drinking a lot more fluids and fast walking. Well I quit the CBD and this pain is making me want to die again. I don’t know what to do. My doc wants nothing to do with CBD so he will not help. I just want to find a way to keep taking it and SLOWLY ween off of some of those meds. I would love for it to drop my BP but not so much so fast. Vany advice?

  • Linda

    I want to go off of seroquelplease help me I’m on 100mg need to taper safely order cbc oil 225

  • Sam

    Hi my son has epilepsy and has started taking Epilim would cbd oil affect his medicine need advice

  • Ruby

    I have fibromyalgia and bipolar disorder (bpII). I have never had a psychotic episode, I am technically bipolar due to one episode of prolonged insomnia without tiring. I am on Lyrica and Nortryptaline for nerve pain and Risperdol (low dose) while I try out Nortryp just in case it activates me. I miss my medical marijuana and cbd, which I was continuing to use until I recently decided to see how I was without it. Am I to conclude that it is a bad idea in general to combine these or is it case by case? I am having trouble with Nortryp side effects but it does give me pain relief. I have a med card and have used medicinal marijuana in the past, but was scared by a dr. who said I shouldn’t combine with Nortryp bc I might become activated due to too much serotonin? Would the same be true of CBD? I think I might have to cross my fingers and hope I haven’t set myself up for an ‘episode’, but if it doesn’t work out taking the both of them I think I’d have to go with the MJ and CBD over the Nortryp due to side effects. I’ll take the nerve pain over the risk and the continuation of these side effects. Haven’t slept in days and days…

  • Denis Murphy

    Hi Jonathan, I am currently taking simvastatin 40 mg for cholesterol and am starting cbd oil 300 mg from pure kana to treat my chronic anxiety. This is a low dose of the cbd, are there known interactions between the 2 at these levels? Thx

  • Steve Smith

    I had my kidney transplant in 1991. Yes that’s a long time ago. I have been taking Cyclosporine along with prednisone for 27 years now. Also I take Metroprolo, Amlodipine and Enalpril for blood pressure. I would sure like to take CBD oil to help treat my joints, feet and bone mass. What do you think?

  • Maryanne Lynch

    my son takes 2 ml of resperdone for autism agitation can iuse CBD oil and lower it the resperdon to 1 mg or less

  • KATHY SELCHERT

    Recently I started taking Jakafi for a blood disorder. My red platelet count is extremely high.
    I’m wondering if CBD oil would be safe for me to take. I deal with pain in my right foot due to a botched surgery.

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