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how does cbd oil interact with other medications

How Does CBD Oil Interact with Other Medications [Guide]

One of the downfalls to the wildly increasing popularity of CBD use is that not a lot of research has been done in regard to its potential interaction with other drugs. Like any drug, CBD is a chemical compound that has specific effects on various pathways in the body. Thus, it’s important to understand whether or not these effects may be dangerous or counterproductive when taken along with other substances.

Fortunately, it’s becoming more and more widely accepted that CBD is generally safe to use, even when taken along with other meds. An updated study published earlier this summer (2017) confirmed the “favorable safety profile” of CBD in humans, and in fact showed that it had a better side effect profile when compared to other medications with similar functions.

Likewise, the U.S. Department of Health issued a statement several years ago claiming that “serious adverse [side] effects are rare with [the use of] cannabis or its constituents.”

That being said, a few studies have shown that in significant enough doses, CBD can inhibit or deactivate a class of liver enzymes that are important for the efficient metabolization (breakdown) of prescription medications. Accumulation of unmetabolized drugs can potentially be dangerous in that it allows for the stagnant buildup of compounds in the liver, as well as a prolonged effect of the drug.

In this article, we’ll go over some common medications that have been known to be affected by continuous, high-dosage CBD use, and also talk about prescriptions for common medical conditions that may pose potentially adverse interactions with the natural cannabinoids like CBD.

First, though, it’s important to understand that this is by NO MEANS a comprehensive guide on which drugs are safe to take with CBD, and which are not. In fact, it’s believed that several of the drugs listed below may actually be enhanced when taken along with CBD. No matter the case, always make sure and speak with a physician or clinical professional before making any changes to your medications.

Interaction of CBD with Cytochrome P450 Enzymes

Cytochrome P450 (CYP) is a class of liver enzymes responsible for the metabolic breakdown of roughly 60% of clinically prescribed medications. In certain doses, several natural plant compounds (including CBD) have been known to temporarily deactivate these enzymes, which can lead to the delayed metabolization and prolonged activity of administered prescription medications (as well as some OTC medications).

While not believed to be life-threatening, prolonged metabolization of prescription medications can potentially lead to accumulation of compounds in the liver, which can present complications. Also, warfarin (a common blood thinning medication) is known to particularly be prone to the effects of deactivated CYP enzymes – individuals who take it (as well as other blood thinning drugs like heparin) are advised to speak with a doctor before administering significant doses of CBD on a regular basis.

Also, diclofenac (which is a NSAID pain reliever), is another medication that’s known to have a prolonged duration when taken simultaneously with CBD. In addition to potential liver complications, prolonged activity and delayed metabolization of these drugs (as well as others) may lead to complications involving the blood.

Since CYP activity affects roughly 60% of all marketed medications, individuals who insist on taking CBD (or other forms of cannabis, for that matter) along with other drugs are advised to monitor any changes in their respective conditions closely. While there have been no known hospitalizations as a direct result of prescription drugs interacting with CBD, there is not nearly enough pharmacologic understanding of the compounds to suggest any range of safe or unsafe doses.

For instance, while one clinical trial in 2013 reported zero CYP interaction with a CBD dose in excess of 40mg, another subsequent trial noted significant deactivation of the enzyme with a dose of 25mg. More in-depth clinical studies are certainly needed in order to better understand the full spectrum of CBD drug interactions.

Other Potential CBD Interactions with Prescription Drugs

Warfarin and diclofenac are certainly not the only medications known to be affected by the temporary deactivation of drug-metabolizing CYP enzymes. Remember, most clinical studies suggest that up to 60% of all marketed medications are broken down (at least in part) by this specific class of enzymes.

Here is a list of several of the most common prescription medications nationwide that are metabolized by Cytochrome P450 enzymes:

  • Blood thinners

As we already talked about, common blood thinner medications like warfarin and heparin are subject to prolonged activity and increased effect when taken simultaneously with CBD, resulting in elevated INR (the International Normalized Ratio is a test used to monitor the effects of warfarin).

Likewise, A 2012 publication in Drug Metabolism and Pharmacokinetics verified that CBD can increase warfarin levels, which suggests that individuals with blood thinner prescriptions need to take considerable precaution if planning on taking frequent doses of CBD. Speak with a physician and monitor any changes in blood or bleeding closely.

  • Medications for gastrointestinal reflux and peptic ulcers

Omeprazole, which includes the drugs Prilosec and Losec (as well as other drugs that treat gastroesophageal reflux disease) can also be affected by frequent CBD use. These drugs are targeted by the specific CYP enzyme CYP2D6, which can be effectively blocked if a significant dose of CBD is taken prior to administration.

  • Antipsychotic medications for schizophrenia, bipolar, autism, etc

Risperidone is a relatively common antipsychotic medication that’s frequently prescribed to treat mild cases of schizophrenia, bipolar disorder, and ASD (autism spectrum disorder). Like omeprazole, it is also targeted for breakdown by CYP enzymes, and high doses of continuous CBD use can potentially lead to its prolonged activation. The same is true for drugs like haloperidol (Haldol), which is a similar antipsychotic medication of the same class.

  • Cholesterol medications

CYP3A4 is another enzyme of the Cytochrome P450 class that’s responsible for breaking down about 25% of all pharmaceutical drugs, according to the DOH (U.S. Department of Health). Frequent CBD use may increase the serum concentration of several popular cholesterol-lowering drugs, including atorvastatin and simvastatin. As of now, however, similarly-functioning statins like pravastatin and rosuvastatin are not believed to be affected by the temporary deactivation of CYP3A4.

  • Blood pressure medications

While CBD by itself is not particularly known to increase blood pressure, the combination of THC and CBD have been known to initiate cardiac stress responses and reduce arterial blood flow. Patients who take medication for blood pressure need to be cognizant of the possibility that marijuana use may enhance the effect of their medication, which can cause serious complications.

  • Epilepsy and seizure medications

While CBD for epilepsy and seizures is generally regarded as an incredibly safe and effective treatment option, a 2015 publication in Epilepsia showed that frequent CBD use can potentially increase levels of the drug Clobazam in children.

Other medications affected by the inhibition of Cytochrome P450 enzymes

The following list of general medications have been acknowledged by the U.S. Department of Health to potentially increase in concentration as a result of CBD-induced inhibition of metabolic liver enzymes:

Drugs metabolized by CYP3A4 enzymes:

  • Macrolides (these include antiobiotics such as Zithromax, Klacid and the erythromycins Erymax, Erythrocin, and Erythroped)
  • Calcium channel blockers (including Norvasc, Cardizem and Tiazac)
  • Benzodiazepines (common anti-anxiety medications including Xanax, Klonopin, and Valium)
  • Cyclosporine (Neoral) (this is an immunosuppressant medication used primarily after organ transplants to lower the risk of organ rejection)
  • Sildenafil (including Viagra and other PDE5 inhibitors like Cialis and Levitra)
  • Antihistamines (these include common OTC medications for allergic reactions: Zyrtec, Benadryl, Allegra, and Claritin)
  • Antiretroviral (ARV) drugs including commonly prescribed HIV/AIDS medications

[Suffering from depression or anxiety? CBD oil extract may be a potential option.]

Drugs metabolized by CYP2D6 enzymes:

  • Tricyclic antidepressants (TCAs including amitriptyline, amoxapine, desipramine (Norpramin), doxepin, imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil) and trimipramine (Surmontil)
  • Antipsychotics
  • Beta blockers and opioid pain medications (including codeine and oxycodone)

It’s important to note, however, that a drug mentioned on the above list does not necessarily mean it shouldn’t be taken simultaneously with CBD. Many people use CBD every day along with some combination of the above medications, without any adverse side effects.

In fact, it’s believed that some medications actually work favorably when taken along with cannabis. The bottom line is that additional clinical study is needed if we’re to determine the complete spectrum of CBD drug interactions.

What About CBD and Alcohol?

In terms of potentially harmful or fatal side effects, combining CBD with alcohol is generally regarded as being safe. However, that’s certainly not to say that it’s recommended; excessive alcohol use (like any excessive drug use) is dangerous, and certainly not advised.

That being said, using CBD (or other forms of cannabis) while drinking alcoholic beverages is not life-threatening or catastrophically harmful in the same way that drinking and taking sleep meds, benzodiazepines, or other depressants is.

Summary

The general takeaway message from all of this should be that CBD is regarded as an incredibly safe and therapeutic medication, with virtually no side effects or risk for addiction/withdrawal. While much more research is needed to fully understand the interactions it may have with other medications, it’s generally accepted that, due to its wide range of use, CBD has the potential to actually eliminate the need to take multiple medications. Or at the very least, reduce one’s current prescription drug use.

Many thousands of people, in fact, have used CBD-based products simultaneously while weaning off other, more dangerous medications such as prescription opiates and antidepressants. (Check out an in-depth article on CBD oil for chronic pain relief here).

Thus, compiling any one complete list of CBD drug interactions is virtually impossible, given the fact that the human body is an INCREDIBLY complex network of interdependent chemical reactions. The pharmacology and physiologic pathways of even the most common and well-studied drugs is not even fully understood.

At this point at least, anecdotal evidence is far more dominant in the cannabis world than is clinical research, and nearly all of that evidence points to CBD as an extremely safe, natural remedy with minimal contraindications.

As we’ve mentioned several times, though, it’s always important to speak with a physician or health professional before implementing any kind of change to your medication. Even though it’s a 100% natural therapeutic compound, at the end of the day CBD is a chemical with a specific physiological pathway, and like all chemicals it presents the opportunity to interact adversely with any number of other drug compounds.

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Customer Reviews Based on 66 reviews

  • Amy Passarelli
    Bring to notice

    CBD is yes an incredibly safe and therapeutic medication, but I would say that always consult your doctor when you are mixing two things together at the same time. Also in case of any emergency, your doc would then know as to why it happened and would be able to manage it in a more appropriate manner.

  • Mike
    Interactions of Inhalers and oxygen and CBD oil?

    I take many inhalers and oxygen, will CBD oil cause any problems or should
    I just go off all of them and only need to take CBD oil.
    Thanks

  • Tim
    Read carefully

    Researchers have found that CBD inhibits the enzymes CYP3A4 and CYP2D6. These are both major metabolizing enzymes for our body, which means CBD has the potential to interact with many substances.

  • Mary Stevens
    Works well always

    To me CBD has never interacted of interfered with other forms of medication. I have tried it with antibiotics, with weed, with multivitamins, it works well for me without any side effects always.

  • Carol
    Thank you!

    I am trying to get off Ativan as I’m so nervous I cry in despair.
    I cut from 3 to 2 a day and it’s so hard. Cbd helps but it takes allot to counterattack my severe nervousness. Thank you for this article. God knows we try to get off these meds that doctors feed to us so they can keep us in bondage to them as they sip of the highlife. This world is ready for a change to help the innocent be freed from big pharma for good. Lord help us all

  • Duane
    How,about CBC balm interactions?

    I may be interested in using a cbd BALM to help alleviate chronic hip and/or lower back pain. Would the drug interactions then perhaps be reduced, in comparison to taking the oil form internally? Or would it be more effective just to take the oil form (orally) for my hip and back pain?

  • Diane Keets
    Thank you for helping

    Thank you for this. I am sadly on a very large amount of meds, all of which are different and probably some shouldn’t be used together. I would love to try CBD for my depression, but worry it will end badly.

  • Linda
    Drug interaction

    I take 7.5mg (half tablet) of mirtazapine to help me sleep 2 or 3 times a week and it normally works very well. Started using cbd oil for anxiety yesterday. Took about 50mg around 4pm (intended to take 20mg but used dropper incorrectly!). Took mirtazapine around midnight but it didn’t help with sleep as it usually does. Is it likely the cbd oil stopped it from working?

  • Harry Steele
    No problems

    I have always drank and taken CBD – no issues

  • Glenda Maul
    ADD

    Can CBD oil be combined with focalin xr for ADD???

  • Steve R Edwards
    I take diltiazem 120 mg,can i also take cbd oil with that?

    can i take cbd oil and diltiazem the same day

  • Paula Jacobs
    Large dosage, when you mention that large daily dosage could effect the liver, what would you consider that amount to be?

    Your article mentions large daily dosage can effect the livers ability to break down rx meds. What would that amount be in your opinion. I have 98% pure oil and the dosage is two 1/2 droppers full twice a day. I have patients concerned about the effect it will have on their blood thinners. CBD opens up receptors in the body and medications will actually work better.

  • Jacqueline martin
    Ms

    Can I take CBD capsules with my other medications- ie = aspirin, amlodipine, bisoprolol, levothyroxine, isosorbide lansoprasole, I had stents put in last year as arteries closing ,& now on atorvastatin 20mg.but I have very painful hip joints & the meds given were paracetamol & co-codermol which do not really touch the ache & pain, I want to know if I could try CBD with the medication that I take already & would this affect my affect medications I take for angina?

  • Nathaniel Mapson
    Advice for athletes

    Does CBD interact with workout supplements such as creatine and protein powders as I use these heavily?

  • John Hernandez
    who can find ?

    You say to consult your physician before taking any of these oils? My question is who knows of a doctor honest enough to tell you the truth on his drugs vs., cbd oils??

  • John Ainsworth
    Help Im an alcoholic

    This is so informative and thorough, thank you for the research! I am looking to start taking CBD for my muscle pain but i am an alcoholic and although I am trying to get help i am worried CBD will impact me badly.

  • Jerry Kraemer
    Propranolol and cbd oil

    I have an essential body tremor and take memorabilia 40 mg daily The propelling keeps my blood pressure at 120/75 but does nothing for my tremor would cbc help my tremor? Does it interact with propranolol? Thanks for any information.

  • Margaretaboile
    Specific Inquest

    I would favor to meet up along anybody at all absorbed with snatching other involved in civil problems about our specialty, connect with me direct using my forum that you think the similar.

  • Emily
    CBD oil and Guanficine

    Hello,
    Thank you for this detailed and understandable explanation about how CBD oil can interact with other drugs. My daughter has Autism and along with that ADHS and Generalized Anxiety Disorder. She takes Buspar for the anxiety, 30 mg daily and Guanficine for the ADHD, 3 mg daily. Guanficine is one of those drugs that one would not consume grapefruit while taking. I am now driving CBD oil to my daughter and it halls with a myriad of things, even she notices the difference. I am currently given her 12 mg in the morning and 12 mg in the evening. Is this safe? Thank you

  • Alex
    Thanks for the info!

    With so much info and anecdotes about the wonders of CBD, I think more people need to see this in particular! I have never seen another article say about the dangers of mixing CBD and other pharma drugs and so this is so important! Thanks for the info!

  • Elisha
    Tylenol

    Can i take Tylenol with my cdb honey stick of 10mgs?

  • Jen Garrnet
    Eliquis Interaction

    I take 5 mg Eliquis twice a day for AF. I have fibromyalgia with sleep issues and moderate pain and am interested in taking no more than 10 mg per day CBD. Is that safe and does taking it sublingually make a difference with any potential Eliquis interaction? Thank you in advance for any advice.

  • Paul Reade
    Can I take cbd and Omeprazole?

    Can I take cbd and 20 mg Omeprazole?

  • Bryan
    CBD recover after exercise?

    I have been on meds for my high cholesterol for 8 months, and want to try CBD to help me recover after exercise as I have started running to help with the cholesterol – do you think this is okay?

  • Colleen Stadnick

    I’m currently taking Warfarin and really hate it and am thinking about switching to Eliquus. How does CBD oil interact with that? Also how about Sertraline (Zoloft), Atenolol, Digoxin and Primidone? Thanks.

  • Pete Marlow

    I am an avid runner – so recently I have been seeing all about how CBD can be great for athletes, and I wanted to try it out for myself. Smoking was a no go – so I tried the Charlottes Web oil pen – and wow does it help! I just apply the oil to my knees after a long distance run and the pain and swelling seems go reduce in no time, it’s great!

  • Ross Jones

    The Charlotte’s Web oils have provided me with a wealth of benefits – not least and most unexpectedly is how well I can get off to sleep at night now! I didnt buy the oil for that purpose, so it a great surprise!

  • Janel Williams

    I have been using the everyday hemp oil for 4 weeks, at the recommended 1ml amount. So far I am finding the results very effective. I have suffered from eczema for years and this seems to really help clear my skin and reduce itchy flakey symptoms!

  • Michael Ranger

    First of all thank you for such an in-depth post, it is really valuable information that you are sharing Jonathan. I do take some of the medications you mentioned here, and I have yet to visit the GO about my CBD use so I think now after reading this I will be going to discuss my options – thank you!

  • Brian Lowe

    I have been taking CBD for my arthritis for about 12 months. I have very high cholesterol and I am also on cholesterol medication, but I haven’t been taking these as often because I don’t want to give up my CBD. What would you advise? I am fearful of going to the doctor in case they tell me to stop taking CBD as it helps my pain so much.

    • norma
      reduce or eliminate cholestrol meds w/Dr.

      I have always wondered if the cholesterol drugs work. Checking with your doctor, of course, find an alternative that is more natural. Check with a holistic doctor. It is a shame that something that works for your pain should be avoided.

  • Linda Maclellan

    Hi Johnathon, I’m taking 1.5 mgs off clonazepam for anxiety and nerves. Will taking CBD oil give me side effects? I just finished cancer treatment…..chemotheraphy (cisplatin) a very low does. I took it once a week for 5 weeks. I also had radiation therapy. Will the CBD oil effect my metabolism, anxiety and nerves?

  • Louise

    Hi i suffer from anxiety and take 100mg quetiapine at night. I have been to gp today and they have put me propranolol 40 3 times a day? Would i be able to uave cbd oil or will it interact i dont really want to ask my doctor at present as thwy will put me off cbd oil???

    • Jonathan Miller

      Using CBD together with Quetiapine may increase side effects such as dizziness, confusion, drowsiness and difficulty concentrating. Please consult with your doctor prior to consuming any CBD

  • Mai Lou

    Which CBD products would you recommend for epilepsy? I haven’t tried CBD yet as i have only recently been diagnosed and unsure what products to try for the better?

  • Filip

    Hi Jonathan i am tapering of mirtazapine, i am down to 30mg from 60 so half way, can i start cbd oil treatment for uc now or do i have to wait to more months until mirta free?
    i have cibdol 4% cbd oil
    please answer quickly, my ulceratis colatis is getting bad again:(
    regards

    • Jonathan Miller

      Hi Filip, I would love to help but I have never used cibdol. I would reach out to the company

  • Anonymous

    Dear Jonathan
    I’m about to take cbd oil for chronic back pain whilst waiting for surgery. I’m on an anti coagulant, Riveroxabane. A syatin

    • Brenda
      Cbd oil and celebrex

      Hello,
      I take Celebrex 100mg twice a day for osteoarthritis and started taking some cbd oil but am feeling quite “ whoozy” should I stop the Celebrex or cbd?

      • Dr. Joe
        celebrate and cbd oil

        Is it sensible that you added cbd oil to your treatment, then you became woozy, that cbd oil is your cause?

  • Maria

    Hi, I am currently taking cellcept, plaquenil, celexa, bupropion. I am currently taking a full dropper at night of elixinol which has 5mg of cbd and 16.7 of hemp oil. Will any of these meds counter act with the cbd oil?

    • Jonathan Miller

      A general good rule of thumb is to find out if your medication is sensitive high levels of citric acid. If so it may not interact well with CBD. FYI:Cytochrome P-450 is an enzyme produced by the liver, which is responsible for about 90 percent of the drug metabolisms that take happens in the body. Cannabidiol tends to suppress this. Therefore if you are taking a drug that interacts with the Cytochrome P-450 the CBD could have a negative impact. Always consult with your doctor before any CBD consumption.

  • Sue

    Can you take CBD oil with taking 20mg of warfarin

  • sherri long

    hello, is 15 mg cbd oil, charlottes web, enough of a dose to try for anxiety?
    I also take prozac 40mg and simvastatin 40mg and ziac, which is a beta blocker/diuretic for blood pressure.
    thanks for your thoughts,

  • Donna Podobinski

    I would like to know what effects are possible when taking CBD oil with the BP meds losartan/hydrochlorothiazide 100/25, and the opiod hydrocodone/acetaminophen 10-325,4-5 times daily.
    I am just beginning the process of decreasing the losartan while beginning the CBD oil. My
    moderate to severe pain is from an assortment of concurrent spinal diseases and sacral/ lumbar arthritis from repetitive injury.
    I am using CBD at 300 mg and realize that my optimum dosing should be with 1000mg, but all the sites suggest starting low and progressing. My breakthrough pain does not respond to 300mg at 1/2 dropper. Higher CBD levels increase interactions. Any help in deciding is greatly appreciated. Thank you in advance.

  • Kip Henderson

    First off let me thank you for putting out a truthful guide to drug interactions between CBD oil and pharmaceutical medications rather than just spouting the party line. But, like everyone else on here I do have a couple of questions. I was told by my family doctor who prescribed the medical marijuana that it didn’t interact with “any” of the pharmaceuticals I was taking. Yet, when I read your blog I see that the FDA has said that it inhibits the liver metabolizing of pretty much every pharmaceutical drug I take which includes diclofenac (arthrotec), citerizine hydrocloride(reactin), Esomeprazole(nexium), and Rosuvastatin(crestor) . So, given the fact that it screws up the metabolizing of those pharmaceuticals would it be safe or prudent for me to use CBD oils in combination with all these pharmaceuticals or would I be playing Russian roulette especially with the Diclofenac which, along with an extended effectiveness has the potential serious liver and blood issues over time despite the daily dosage of the CBD oil used.

  • Gloria Mulcahy

    Hi Jonathan,
    I live in Ireland where its relatively new that CBD oil is available, just to tell you i have been suffering 5 years with bulging discs and only a month ago had an epidural for the second time and to be honest i am 100 times worse since having it done. My regular every day meds are Aspirin 75mg as a maintenance dose, lustral 100mg, Rosuvastatin 10mg & Nexium 40mg. Now since coming out of hospital for the past month i am on pregablin {Lyrica} 75mg 3 times daily, Targin 10/5mg 2 per day 12 hours apart, Tramadol 50mg up to 3 times per day when needed and paracetamol when needed. I finally today was able to buy CBD + Jacob Hooy 10 ml of 2,75% [If that makes any sense as thats whats on the bottle] so my questions are, how soon can i take it, do i stop taking the meds since coming out of hosp first,? I would appreciate your reply and recommendation. I am in terrible pain down my right leg from sciatic nerve & foot goes numb. I also have fibromyalgia. Thanks Jonathan.
    Kind Regards, Gloria.

  • Peter cross

    Is it safe to tack if with out inform,ming my doc,simms diabetic neiopathic Pain, insulin,met form, auto arthritus

  • Ashton Huffman

    I take 30 mg’s Of diazepam a day for 5 years plus 5mg’s of lisinopril. The diazepam doesn’t help my anxiety and panic at all but it helps my vertigo. Is it safe to take the oil with my current meds?

    • Jonathan Miller

      In my experience they shouldn’t interact but again speak to your doctor.

  • Irene

    I am suffering greatly with I think IBS or Diverticulitis . I take Warfarin for AF, Cardicor. . Losartin.and simvastatin. Would it be wise of me to try the CBD OIL to try to relieve my painful. Stomach . I appreciate your wise advice .

  • Nancy

    My 14 yr old is on Latuda. 60mg once daily at night. I have just purchased my first everyday advanced hemp oil?
    What advice do you have?

  • Shannon Thier

    Will lexapro interact with the CBD oil?

  • Jo Christensen

    Does CBD oil interfere with Prednisolone (note: not Prednisone) or vice-versa? I am considering very low dose CBD oil in lieu of toxic chemotherapy for my cat’s intestinal lymphoma, but would like him to stay on the Prednisolone so as to keep-up his appetite and general well-feeling. Note that he will also need to continue Sucralfate for another week or two in order to heal a stomach ulcer.

  • JOHN FEDORUK

    i take cocersyl plus for blood pressure// started taking 15 drops of straight CBD 3 times a day,
    doing my regular routine and my BP reading went through the roof 170/95 after the 1st day
    normal readings for me were 130/78, should i stop the cbd

  • Raj

    Do you know if CBD oil can conflict with ayurvedic natural medicines. I read on your site that certain enzymes in the liver to break down medicines might be deactivated due to CBD oil. Appreciate your view.

  • Ron Teck

    How does hemp oil react with antihistamines and blood pressure meds, are there any risks.

  • Tammy M

    Oh and from what I understand is it’s made my meds more potent is why it dropped the BP so much. It does drop BP some but it warned that it could make meds more potent

  • Tammy M

    I am on Toprol er, Lisinopril, Verapamil sr, and Hydrochlorothiazide and have been for over 5 years. This is the only combo of drugs that has ever gotten my blood pressure close to normal. It still stays on the high side of normal but at least I have had that. Putting that aside, I started on and for pain about 2 months ago and my BP started dropping. Now I started getting numbers like 84/49 and 90/51 so I immediately started doing things to pull my BP up like drinking a lot more fluids and fast walking. Well I quit the CBD and this pain is making me want to die again. I don’t know what to do. My doc wants nothing to do with CBD so he will not help. I just want to find a way to keep taking it and SLOWLY ween off of some of those meds. I would love for it to drop my BP but not so much so fast. Vany advice?

  • Linda

    I want to go off of seroquelplease help me I’m on 100mg need to taper safely order cbc oil 225

  • Sam

    Hi my son has epilepsy and has started taking Epilim would cbd oil affect his medicine need advice

  • Ruby

    I have fibromyalgia and bipolar disorder (bpII). I have never had a psychotic episode, I am technically bipolar due to one episode of prolonged insomnia without tiring. I am on Lyrica and Nortryptaline for nerve pain and Risperdol (low dose) while I try out Nortryp just in case it activates me. I miss my medical marijuana and cbd, which I was continuing to use until I recently decided to see how I was without it. Am I to conclude that it is a bad idea in general to combine these or is it case by case? I am having trouble with Nortryp side effects but it does give me pain relief. I have a med card and have used medicinal marijuana in the past, but was scared by a dr. who said I shouldn’t combine with Nortryp bc I might become activated due to too much serotonin? Would the same be true of CBD? I think I might have to cross my fingers and hope I haven’t set myself up for an ‘episode’, but if it doesn’t work out taking the both of them I think I’d have to go with the MJ and CBD over the Nortryp due to side effects. I’ll take the nerve pain over the risk and the continuation of these side effects. Haven’t slept in days and days…

  • Denis Murphy

    Hi Jonathan, I am currently taking simvastatin 40 mg for cholesterol and am starting cbd oil 300 mg from pure kana to treat my chronic anxiety. This is a low dose of the cbd, are there known interactions between the 2 at these levels? Thx

  • Steve Smith

    I had my kidney transplant in 1991. Yes that’s a long time ago. I have been taking Cyclosporine along with prednisone for 27 years now. Also I take Metroprolo, Amlodipine and Enalpril for blood pressure. I would sure like to take CBD oil to help treat my joints, feet and bone mass. What do you think?

  • Maryanne Lynch

    my son takes 2 ml of resperdone for autism agitation can iuse CBD oil and lower it the resperdon to 1 mg or less

  • KATHY SELCHERT

    Recently I started taking Jakafi for a blood disorder. My red platelet count is extremely high.
    I’m wondering if CBD oil would be safe for me to take. I deal with pain in my right foot due to a botched surgery.

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