10 Top Studies on CBD for 2018 [Exploring the Science]

August 27, 2018

10 Top Studies on CBD for 2018 [Exploring the Science]

CBD is a compound found in cannabis that might just revolutionize how people view medicine and their medical treatment options. In fact, CBD has already come a long way in establishing itself as a medical phenomenon. Over the past decade, there has been an increasing number of studies done on cannabis, and more specifically on CBD and its potential to help treat various medical conditions.

Over the past year, plenty of CBD-related studies have been conducted across multiple countries and institutions. Many of these studies contribute to the growing understanding and acceptance of CBD. Here are ten medical research studies from this year that have made a significant impact on the medical community.

1. Transdermal CBD for the Treatment of Non-Opioid Addictions

Over the past few years, CBD has emerged as a potential treatment option for various types of addiction. Whether it’s tobacco, opioids, or hard drugs like cocaine and heroin, CBD may just help addicts to overcome their addiction.

In a recent study that was published in March of this year, researchers looked at the ability of CBD to protect against factors that promote relapse to cocaine and alcohol use. Profound withdrawal symptoms like anxiety and heightened impulsive behavior are some of the factors that promote relapse into drug seeking behaviors. Since CBD isn’t thought to have any addictive properties, it could possibly act as an anti-addiction tool if it helps to reduce the anxiety and impulsive decision making that come as a result of drug withdrawal.

What made this study unique was that CBD was administered transdermally, i.e., similar to a gel or patch in humans, which is different from the standard injection method that is often used in rodent research. Unsurprisingly, scientists found that CBD had the potential to reduce impulsive decision making and anxiety, which are two core behaviors that promote drug relapse.

2. CBD’s Fast-Acting, Long-Lasting Antidepressant Effects in Rodents

Over the last few years, CBD has emerged as a somewhat promising antidepressant. It is estimated that 20% of the world’s population is affected by clinical depression. The problem is that most of the current treatment options are sub-par. Shockingly, close to a third of patients don’t respond to treatment, and if they do, it can take weeks for the therapeutic effects to kick in.

This is where CBD comes in. In June this year, scientists in Brazil published the most comprehensive report to date on CBD and how it works in preclinical rodent models of depression. As part of the study, a range of behavioral tests was done on different strains of rats and mice, some of which were prone to depression. The study found that CBD reduced some of the behaviors associated with depression.

This was the first study to establish CBD’s antidepressant benefits across a range of behavioral and rodent models, and to give a mechanic insight for its effects. The antidepressant qualities displayed by CBD were associated with changes in brain chemistry in regions that are linked to the disorder. Levels of the brain chemical BDNF found in the hippocampus and prefrontal cortex was increased by CBD. It also increased the number of connections between brain cells. These are both factors that are reduced by depression and restoring them is a hallmark of effective treatment.

3. CBD Treats Brain Changes Caused by Regular Cannabis Use

This study is one of the most interesting to date. CBD may treat brain changes that are caused by cannabis, the very plant that CBD originates from. Using THC-rich cannabis regularly could change the way that the brain functions, and unfortunately these changes are not always positive and often occur in a particular region of the brain known as the hippocampus. Changes in this part of the brain can affect cognitive performance, resilience to stressors, and control over anxiety.

On the positive side, it’s becoming increasingly apparent that CBD could protect the brain against the effects of THC. Thus, CBD may prevent THC-induced changes by acting as a protective tool. In a study conducted by neuroscientists in Australia, it was discovered that CBD affected hippocampus anatomy in regular marijuana consumers. As part of the study, subjects were administered four 50 mg capsules of CBD each day. At the beginning of the study, parts of the hippocampus were smaller in cannabis users when compared to participants that didn’t use cannabis. However, ten weeks after the CBD treatment, many of those regions increased remarkably in size.

There are a number of reasons why the ability of CBD to recover hippocampal size is so significant, one of the most relevant being that CBD could act as a promising preventative or therapeutic tool to combat a few of the long-term negative consequences associated with the use of THC.

4. CBD May Help Curb the Frequency of Epileptic Seizures

In a 2018 study that was published in Neuroscience, researchers provided further evidence suggesting that CBD is effective in reducing seizures in people with epilepsy. CBD was studied in a new large-scale, controlled, and randomized trial to significantly reduce the number of seizures in patients who suffered from a severe form of epilepsy, known as Lennox–Gastaut syndrome.

As part of the study, two doses of CBD were compared to a placebo. The researchers reported a 41.9% reduction in “drop seizures”, which is a type of seizure that results in severe loss of balance and muscle control, by those patients who took a 20 mg dose of CBD, a 37.2% reduction in those who took a 10 mg of CBD, and a 17.2% reduction in those who took a placebo.

This new study has added extensive evidence of the effectiveness of CBD to reduce seizures in a severe form of epilepsy and is the first study of its kind that offers more information on proper dosing. The study looked at an investigation liquid – an oral formulation of CBD – known as Epidiolex. This is a product that is manufactured by GW Pharmaceuticals, who funded the trial.

5. CBD Oil Can Help Increase Comfort and Activity in Dogs with Osteoarthritis

A new pharmacokinetic and clinical study* that was recently conducted at Cornell suggests that 2 mg of CBD oil administered twice daily could help to increase the comfort and activity in dogs who suffer from osteoarthritis. The study was headed by Joe Wakshlag, who is a section chief of nutrition and associate professor at Cornell. The objective of the study was to determine the safety, the basic oral pharmacokinetics, and to assess the efficacy of CBD oil in dogs who suffer from osteoarthritis.

The study tested two different doses of CBD – 2 mg and 8 mg and determined the elimination half-life to be 4.2 hours at both doses. There were no adverse side effects noted at either dosage, but serum chemistry showed that alkaline phosphatase activity increased. As part of the study, dogs received either 2 mg of CBD oil every 12 weeks, or they received placebo oil. The dogs were treated for four weeks with a two week washout period. The veterinary assessment found that the CBD oil significantly reduced pain and increased activity level.

6. CBD from Marijuana Combined with Chemotherapy Tripled Cancer Survival Rates in Mice

According to a new study published on Oncogene on 30 July 2018, mice with pancreatic cancer who were treated with a combination of CBD and chemotherapy survived nearly three times longer than those who were treated with chemotherapy alone.

CBD has already proven to improve some of the side effects of chemotherapy like vomiting and nausea, and the latest results are providing more justification for testing in humans. According to the study, pancreatic cancer is among the deadliest types of cancer in the world when it comes to the overall survival rate.

While this study has not yet been replicated in humans, the research results highlight the importance of conducting further research into the cannabis compounds and more specifically, CBD.

7. CBD May Reduce Pain in Patients with Kidney Transplants

In one of the latest 2018 studies* on the medicinal effects of cannabidiol, research was done using CBD to treat chronic pain in kidney transplant patients in Uruguay. The study assessed the safety, effect, and possible drug interactions in kidney transplant patients who were treated with CBD for chronic pain.

As part of the study, patients were administered doses of CBD that increased from 50 to 150 mg twice a day for three weeks. Blood count, liver enzymes, liver function, creatine, and drug levels were looked at every 48 hours for the first week and once a week thereafter.

The results found that, out of the seven patients who were studied, two patients had total pain improvement, four had a partial response in the first 15 days, and one experienced no change. The adverse effects that were experienced were dizziness, dry mouth, and nausea. However, during the follow-up process, CBD was well-tolerated, and there were no severe side effects.

8. CBD May Be Helpful in Schizophrenia According to Clinical Study

In a randomized controlled trial conducted this year and published in the American Journal of Psychiatry*, it was found that CBD has positive effects in patients with schizophrenia.

Researchers assessed the effectiveness and safety of CBD in patients who have schizophrenia, and as part of the study, patients with schizophrenia were randomized in a 1:1 ratio to receive CBD or a placebo alongside their antipsychotic medication. After six weeks of treatment, the group who had been treated with CBD had lower levels of positive psychotic symptoms when compared with the placebo group. This group was also more likely to be rated as improved and as not severely unwell by the treating clinician.

The findings strongly suggest that CBD has beneficial effects in patients with schizophrenia. The CBD was well tolerated by patients, and the rates of adverse effects were similar between CBD and the placebo group.

9. A CBD-rich Cannabis Extract May Be Useful in Children with Autism

A 2018 study* published in the journal Neurology assessed the tolerability, safety, and efficacy of CBD-based medical marijuana, as a potential therapy for behavioral problems in children with autism.

As part of the study, sixty children with ASD were treated with oral CBD and THC at a ratio of 20:1. Following the cannabis treatment, it was found that behavioral outbreaks were either much improved or very much improved in 61% of patients. The anxiety and communication skills were much improved or very much improved by 39% and 47% respectively. Disruptive behavior was improved in 29% of patients.

10. CBD May Be Helpful in Tobacco Dependency

A study* published by Hindocha C. et al. in the Addiction Journal has found that CBD may be a promising novel smoking cessation treatment due to its anxiolytic properties, minimal side-effects and research showing it could modify drug cue salience.

As part of the study, a total of thirty non-treatment seeking, cigarette dependent smokers were recruited from the community. Either an 800 mg oral dose of CBD or a matched placebo was administered to participants. Craving, side-effects, withdrawal, blood pressure, and heart rate were assessed repeatedly.

Tobacco abstinence was increased in patients who received the placebo when compared to satiety. When compared with a placebo, CBD reduced explicit pleasantness of cigarette images. Craving and withdrawal were also affected by CBD. Ultimately, it was found that a single 800 mg dose of CBD reduced the pleasantness and salience of cigarette cues when compared to placebo after overnight cigarette abstinence in dependent smokers.

Final thoughts on top 10 studies on CBD for 2018

It is clear that research into CBD is expanding rapidly and becoming a lot more extensive. These studies have displayed a broad spectrum of findings, ranging from the treatment of serious medical disorders such as schizophrenia to tobacco dependency. Ultimately, these aren’t the first studies to be done on the efficacy of CBD, and they surely won’t be the last.

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Getting Started with CBD Oil

If you suffer from anxiety (like me), depression or pain and are looking to get started with CBD oil, you need information on how to buy CBD oil, or you’re simply looking to learn more about CBD products, you’ve arrived at the right place.

What is CBD?

Cannabidiol, aka CBD, is a compound found in the cannabis plant that has significant medical benefits. CBD can be extracted from two different species of the Cannabis Sativa L plant, which include Cannabis and Hemp. Unlike its rival THC, CBD does not make people feel “stoned” and can actually counteract the psychoactivity of THC.

One of the main advantages of CBD is its non-psychoactive affect making it a great option for people looking for relief from inflammation, anxiety, insomnia, seizures, spasms, and other conditions.
As I mentioned above the primary distinction between Hemp and CBD oil is the part of the plant they are derived from and what parts of the plant are used to create the oil. Hemp oil is typically made from pressing cannabis seeds to extract the fatty oil from within, while some that have mastered the CBD extraction process also use the flowers as they contain high percentages of CBD. CBD oil, on the other hand, is usually made from the flowers of cannabis plant through various extraction methods.

How Does CBD Affect Your Body?

The way marijuana affects your body varies from person to person as it will often depend on genetics, tolerance to the cannabinoids, medical health, DNA, and more. It also depends on the way you consume the CBD, for example, the effects of vaping CBD are far different to smoking it in the form of high-CBD cannabis strains. 

CBD and the way it affects us is still of somewhat a mystery to researchers they still try to figure out how it effects the EndoCannabinoid system. During the previous century, it was discovered that our bodies have receptors within the brain and central nervous system. Specific cannabinoids such as CBD bind to those receptors and activate the EndoCannabinoid System (ECS). This then provides a wide range of psychological and physical benefits helping the body.

Without going into specifics, cannabinoids signal to the body to create endocannabinoids and build more receptors. This helps the body to limit things associated with pain and inflammation, repairs cells and provides a wide range of other health benefits. Unlike other cannabinoids, CBD is thought to be the ultimate anti-inflammatory cannabinoid.

Want to learn more about how CBD works read: How Long Does it Take CBD to Work

Medical Benefits of CBD

There is a misconception as to whether CBD can help treat patients, similar to pharmaceutical medicine, but thanks to the internet and a few different medical studies patients and researchers have been exposing their findings on how CBD oil is helping to cure a wide range of medical conditions.

The most popular story was the one of Charlotte Figi. At the time Charlotte was only 6 years old. As a little girl, she was experiencing over 300 epileptic seizures per week until she was successfully treated by a CBD-rich strain oil, later named Charlotte’s Web.

The high-quality CBD oil, changed her life, helping her to overcome a 6-year battle. Since her story hit the news, CBD and other cannabinoids of the cannabis plant are constantly being researched to understand how they can help to treat different medical conditions. As a matter of fact, CBD has been thought to help treat over 170 medical conditions, among them severe conditions such as Anorexia, Cancer, Arthritis, Depression, Anxiety, Chronic Pain, Insomnia, Glaucoma, multiple sclerosis and PTSD.

Recent studies have even shown that CBD, may cure life-threatening diseases by altering genes. Other studies have proven that it might even be an effective treatment for osteoarthritis and chronic pain.

The way that CBD works is that it interacts with receptors located in different parts of the central nervous system. These receptors are called CB1 and CB2. Both reflect the areas of the brain they interact with such as the limbic system. When taking CBD, this cannabinoid locks in on these receptors and affects the body in different ways. For example, it can help to block the pain caused by specific medical conditions.

While numerous studies have shown promising results, it is important to understand that CBD research is still at premature stages. A 2011 study that researched CBD for fibromyalgia showed extremely promising results. 56 of 112 participants who took CBD in the form of oil saw a great reduction in their symptoms and pain, while those using traditional methods didn’t see hardly any improvement.

Can you Buy CBD if you live in an illegal state?

The process is not cut-&-dry, and but thanks to the Farm Bill of 2014, forms of CBD can now be delivered to your doorstep. Those that live in recreational states can purchase CBD cannabis oil which is high in potency and extremely effective for helping to treat severe medical conditions, while those that live in other states that are not medical or recreational can benefit from CBD hemp oil. CBD Hemp oil is perfect for helping to treat a wide range of conditions including anxiety, depression and acute pain. 

Who is NaturalWellNessCBDOil?

My name is Jonathan, and I’ve created this loving resource that is packed with information about CBD oil. I am growing a community on Facebook and are constantly engaging with different people to help them make more informed decisions. I review products on a daily basis and provide unbiased reviews about some of the top CBD oil manufacturers. All the information on the site is FREE; I only ask that you help to share the information you find on the site with other people that are suffering. 

To your health and happiness.