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Will CBD Liposomes Change the Cannabis Market Forever?

September 24, 2018

Will CBD Liposomes Change the Cannabis Market Forever?

If you’ve never heard of the word liposomes before, you might immediately think of liposuctions and fat. And in fact, you’d be somewhat right – the root word “-lipo” does essentially mean fat.

CBD liposomes are a new way of consuming CBD where instead of mixing CBD in inert oils or smoking it directly in the form of a joint, you ingest it via a liposome, which is basically a tiny sphere of cholesterol with the ability to mix with water-based substances.

This might seem far more confusing than just taking CBD oil directly, but it’s actually revolutionizing the way in which medicines – and even food supplements – are being taken.

Could newly introduced CBD liposomes change the way cannabis is consumed? Keep on reading to find out.

What are Liposomes, Anyway?

To understand the CBD liposome market and its growth, you first need to actually understand what a liposome is.

Liposomes are very much what their name would suggest; small spheres of cholesterol – essentially fat – which contain naturally occurring phospholipids. Without making it even more complicated, phospholipids are a class of fats that can form lipid bilayers – as in the outer membranes of our cells. This means that they are essentially a double-ended fat molecule, one with a normal, hydrophobic fatty acid, and another with a head consisting of a phosphate group.

This might sound like endless, unimportant chemistry, but this is actually extremely significant for medicine and in terms of being able to understand the benefits of taking CBD liposomes as opposed to other forms of CBD like oils or edibles.

Generally speaking, fats and water do not mix; if you were to mix oil and water, you’ll find that, instead of mixing together like other liquids, the oil will settle on the surface. This is because of the electron charge of different molecules; water-based molecules have both a positive and a negative charge, similar in a sense to a conventional battery.

This means that, were they to try to bond with another substance, they could only do so with other water-based molecules because of their charge.

Fat-soluble molecules, however, have essentially no charge on either end. This means that, while fatty substances are happy to bond with one another, they cannot mix with water-based substances.

In the case of phosphate group liposomes, however, it’s a bit different. Because liposomes possess both the standard hydrophobic, non-electrically charged ends and a hydrophilic (that means it “likes” water!) end, they can bridge the gap between fat and water substances.

What this basically means in practical terms is that liposomes are able to help fat-based substances mix with water-based substances. When you imbibe cannabinoids (of which CBD is one), you have to contend with the fact that the active compounds are fat-based. This is why when you make cannabutter for use in baking, you have to use a butter to get the cannabinoids out, as they do not mix into water.

When you consume CBD or THC, your body has to work to separate the fat-soluble cannabinoids and mix it with the water components of your body – just like your bloodstream and your muscle tissue.

Due to the difference in charge type, this results in a certain amount of loss when you are imbibing cannabinoids, as some of it simply can’t be absorbed by the body. In using liposomes capsules, this can be averted.

By incorporating CBD into liposomes, the CBD molecules have a much easier time entering the body via its ability to adhere to compounds in the bloodstream. And more importantly, it means that more of the active CBD compound can become available for use, as opposed to other methods (like smoking or consuming edibles) wherein a large percentage of the CBD is lost through metabolism.

As you’ll see, this can have a huge benefit for those with a deficiency of endocannabinoid receptors.

Why CBD Liposomes are Particularly Effective

The endocannabinoid system is the system that runs throughout our body and is responsible for a variety of healing effects and regulatory controls, including things like cell regeneration and dopamine release. The ECS is made up of cannabinoid receptors, which are triggered by our body’s naturally-produced endocannabinoids.

However, it is possible for an individual to not have enough endocannabinoid receptors, or to not produce enough endocannabinoid molecules. This has been theorized to be partially responsible for the development of numerous conditions (such as Alzheimer’s disease and instances of chronic pain), but most significantly of al,l it means that certain people struggle to gain an effect from cannabinoids.

While this means that these people might not be able to get high from THC, it also means that CBD will have trouble being picked up by the body’s ECS system. For these people especially, CBD liposomes may have the potential to be incredibly helpful.

As the liposome is made up of both fat-compatible and water-compatible molecules, it means the active compound is able to be carried into the body’s bloodstream very efficiently. This may help overcome certain deficiencies inherent in suffering from an endocannabinoid receptor deficiency.

Moreover, this makes CBD liposomes extremely useful for those who may have an endocannabinoid deficiency; liposomes increase the base transference rate of CBD into the human body, regardless of the body’s ability to process cannabinoids.

This all seems to add up to making CBD liposomes the best possible choice as far as the method of CBD ingestion, right?

CBD Liposomes: Are They Worth the Extra Cost?

The problem with considering CBD liposomes over more traditional methods of CBD consumption, such as CBD oils or dabs (or even regular smoking marijuana), is that there isn’t as much research undertaken into liposomes.

Though originally discovered over 60 years ago, liposomes lack the breadth of research conducted into the other methods of CBD intake. In essentially every study conducted into the efficacy of CBD, pure CBD extracts suspended in oil are used as the administrator.

We aren’t 100% sure of the total effect that using CBD liposomes has in terms of a replacement for CBD oils. Though we understand the mechanisms behind CBD liposomes, there isn’t really much knowledge with regard to their long-term impacts on the human body.

Additionally, liposomes have only been used in the “niche” pharmaceutical market, often considered unnecessary to delve too much into. While it is true that, in recent years, this has changed, there is still not a lot of research conducted into the merits and overall benefits of liposomes.

There has, however, been a significant study into the uses of liposomes, conducted by researchers for the Journal of Controlled Release. In the study, researchers looked into the ability of transdermal liposomes for delivering CBD, and whether or not it demonstrated an increased efficiency compared to other methods.

The study concluded that CBD and phosphatidylcholine, the form of liposome used in the experiment, formed a eutectic mixture; meaning that the mixture was actually a true mix of substances (the same as if the CBD was mixed into oil).

The study then tested transdermal cannabidiol application into mice, and found that through mixing it with liposomes, CBD intake and rate of efficacy was significantly increased. The experiment essentially demonstrated that, by mixing CBD with liposomes, you are able to get the skin to absorb it, thereby allowing for a potentially new form of CBD intake.

Previously, you needed to either smoke, vaporize or ingest CBD orally, which exposed you to the risk of losing some of the active compound through biological inefficiencies within the digestive system. Though there exists a multitude of topical CBD products, the rate of topical absorption of cannabinoids remains relatively low.

Lodzki et al.’s study revealed that liposomes enable CBD’s absorption into the skin, showing even greater levels of efficacy than if imbibed in more “traditional” ways. This is of particular significance when treating localized injuries or sites of inflammation, as the ability to apply CBD directly to an affected area would allow the active compound to work on the CB2 receptors in that specific area.

[Related article: Does CBD really work to help reduce inflammation in arthritis?]

So, Will CBD Liposomes Change Everything?

At present, it’s impossible to say whether or not the cannabis market will be significantly affected by the appearance of CBD liposomes. Despite their existence for over half a century, liposomes are still new in the sense that there is a lack of in-depth studies conducted into their efficacy.

Simply put, we don’t know enough about the long-term effects of liposomes, nor do we absolutely understand their rate of efficiency other than the demonstrated increased rate of initial absorption.

Additionally, CBD liposome production is a great deal more expensive than CBD extracts into oils, so manufacturers have less of an incentive to switch from one production method to another.

Final Thoughts on CBD Liposomes

As interesting as it would be to be able to use the seemingly advanced technology of CBD liposomes in the world of cannabis, we simply don’t know enough about them to make the switch.

Perhaps with a few more years of additional study – and a backlog of demonstrated efficacy – people could begin to make the switch to using liposomes and experience a reduction in CBD loss during consumption. Until then, CBD liposomes will likely be limited to those with an endocannabinoid receptor deficiency, and/or those that want to experiment with new and interesting ways to consume therapeutic cannabinoids. CBD liposomes may not be a reality today, but they might become the cannabis intake method of choice in the future.

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Jonathan Miller
Jonathan Miller, age 53 is an Ex Railyard Engineer who suffers from chronic back pain and anxiety. Jonathan’s goal was to create an unbiased site that would provide anyone who seeks help in CBD oil as a treatment, with accurate and helpful information.
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Getting Started with CBD Oil

If you suffer from anxiety (like me), depression or pain and are looking to get started with CBD oil, you need information on how to buy CBD oil, or you’re simply looking to learn more about CBD products, you’ve arrived at the right place.

What is CBD?

Cannabidiol, aka CBD, is a compound found in the cannabis plant that has significant medical benefits. CBD can be extracted from two different species of the Cannabis Sativa L plant, which include Cannabis and Hemp. Unlike its rival THC, CBD does not make people feel “stoned” and can actually counteract the psychoactivity of THC.

One of the main advantages of CBD is its non-psychoactive affect making it a great option for people looking for relief from inflammation, anxiety, insomnia, seizures, spasms, and other conditions.
As I mentioned above the primary distinction between Hemp and CBD oil is the part of the plant they are derived from and what parts of the plant are used to create the oil. Hemp oil is typically made from pressing cannabis seeds to extract the fatty oil from within, while some that have mastered the CBD extraction process also use the flowers as they contain high percentages of CBD. CBD oil, on the other hand, is usually made from the flowers of cannabis plant through various extraction methods.

How Does CBD Affect Your Body?

The way marijuana affects your body varies from person to person as it will often depend on genetics, tolerance to the cannabinoids, medical health, DNA, and more. It also depends on the way you consume the CBD, for example, the effects of vaping CBD are far different to smoking it in the form of high-CBD cannabis strains. 

CBD and the way it affects us is still of somewhat a mystery to researchers they still try to figure out how it effects the EndoCannabinoid system. During the previous century, it was discovered that our bodies have receptors within the brain and central nervous system. Specific cannabinoids such as CBD bind to those receptors and activate the EndoCannabinoid System (ECS). This then provides a wide range of psychological and physical benefits helping the body.

Without going into specifics, cannabinoids signal to the body to create endocannabinoids and build more receptors. This helps the body to limit things associated with pain and inflammation, repairs cells and provides a wide range of other health benefits. Unlike other cannabinoids, CBD is thought to be the ultimate anti-inflammatory cannabinoid.

Want to learn more about how CBD works read: How Long Does it Take CBD to Work

Medical Benefits of CBD

There is a misconception as to whether CBD can help treat patients, similar to pharmaceutical medicine, but thanks to the internet and a few different medical studies patients and researchers have been exposing their findings on how CBD oil is helping to cure a wide range of medical conditions.

The most popular story was the one of Charlotte Figi. At the time Charlotte was only 6 years old. As a little girl, she was experiencing over 300 epileptic seizures per week until she was successfully treated by a CBD-rich strain oil, later named Charlotte’s Web.

The high-quality CBD oil, changed her life, helping her to overcome a 6-year battle. Since her story hit the news, CBD and other cannabinoids of the cannabis plant are constantly being researched to understand how they can help to treat different medical conditions. As a matter of fact, CBD has been thought to help treat over 170 medical conditions, among them severe conditions such as Anorexia, Cancer, Arthritis, Depression, Anxiety, Chronic Pain, Insomnia, Glaucoma, multiple sclerosis and PTSD.

Recent studies have even shown that CBD, may cure life-threatening diseases by altering genes. Other studies have proven that it might even be an effective treatment for osteoarthritis and chronic pain.

The way that CBD works is that it interacts with receptors located in different parts of the central nervous system. These receptors are called CB1 and CB2. Both reflect the areas of the brain they interact with such as the limbic system. When taking CBD, this cannabinoid locks in on these receptors and affects the body in different ways. For example, it can help to block the pain caused by specific medical conditions.

While numerous studies have shown promising results, it is important to understand that CBD research is still at premature stages. A 2011 study that researched CBD for fibromyalgia showed extremely promising results. 56 of 112 participants who took CBD in the form of oil saw a great reduction in their symptoms and pain, while those using traditional methods didn’t see hardly any improvement.

Can you Buy CBD if you live in an illegal state?

The process is not cut-&-dry, and but thanks to the Farm Bill of 2014, forms of CBD can now be delivered to your doorstep. Those that live in recreational states can purchase CBD cannabis oil which is high in potency and extremely effective for helping to treat severe medical conditions, while those that live in other states that are not medical or recreational can benefit from CBD hemp oil. CBD Hemp oil is perfect for helping to treat a wide range of conditions including anxiety, depression and acute pain. 

Who is NaturalWellNessCBDOil?

My name is Jonathan, and I’ve created this loving resource that is packed with information about CBD oil. I am growing a community on Facebook and are constantly engaging with different people to help them make more informed decisions. I review products on a daily basis and provide unbiased reviews about some of the top CBD oil manufacturers. All the information on the site is FREE; I only ask that you help to share the information you find on the site with other people that are suffering. 

To your health and happiness.